CBD for Dummies (A basic intro to CBD and its uses)

Medical Cannabis has a strong image around the globe. Medicinal department incredibly uses advantages of this plant for relieving different illnesses. Cannabis is otherwise called as medical marijuana. It contains certain active compounds known as cannabinoids which are in charge of cannabis’ effect on people. In this plant, there are different cannabinoids from which the most imperative cannabinoid, CBD (Cannabidiol) will be talked about in detail in this article. The way that CBD does not have any side effects it is in the spotlight these days. As CBD is acquired from a natural source, it is considered as a herbal item which is safe for everybody.

HOW IT WORKS

CBD (Cannabidiol) is a chief cannabinoid found in medical cannabis. Its main feature is that it is nonpsychoactive. It eradicates the harming impacts of THC such as intoxication, drowsiness, getting high and memory impairment. The endocannabinoid system holds a solid part with CBD. It joins with the cannabinoid receptors in different parts of the body predominantly in the Central nervous system by the antipsychotic impact (Tokes, 2016). Its medical advantages are broad, and CBD is also very simple to utilize. It is for the most part used in oil form, vape, capsules and so on, people can use it according to their need. As CBD is a nonpsychoactive compound, it helps to eradicate psychoactive effect created by the other compounds present in the cannabis plant.

MEDICAL BENEFITS OF CBD

CBD research shows that it is very helpful in epilepsy, chronic pain, anxiety depression, diabetes, psychotic disorders, inflammation, and cancer more detail over this is as follows:

  • Chronic Pain: CBD works as an analgesic in different illnesses (Mechoulam, Peters, Murillo-Rodriguez, & Hanu{\v{s}}, 2007). A randomized clinical trial suggested that CBD is very effective in curing multiple sclerosis pain and cancer pain (Russo, 2008).

  • Epilepsy: It is helpful in curing epilepsy especially in the young children  (Devinsky, et al., 2014)

  • Anxiety: CBD lowers the level of anxiety before and after any trauma.
    Anti-inflammatory: CBD possess anti-inflammatory features, and it is mainly recommended to decrease inflammation in many diseases that include cancers, oral disorders, etc.  (Burstein, 2015). It is also helpful in curing inflammation symptoms of arthritis and other disorders with the same symptoms.

  • Psychotic Disorders: A transitional study report of about thirty years suggested that CBD successfully helps psychotic disorders such as schizophrenia disorder (Zuardi, Crippa, Hallak, Bhattacharyya, & Atakan, 2012).

  • Diabetes: professionals have conducted  some investigations to assess the effectiveness of CBD in diabetes  which ended very successfully with positive results (Weiss, Zeira, Reich, Slavin, & Raz, 2008)

  • Cancer:  It is recommended to decrease the symptoms of all sorts of cancers and tumors (Burstein, 2015).

  • Antidepressant: A receptor (5-HT1A) joins CBD induced antidepressant effect and increase levels of glutamate that is the reason it is known to be a fast-acting antidepressant in the medical field (Linge, Jim{\’e}nez-S{\’a}nchez, Campa, Pilar-Cu{\’e}llar, & Vidal, 2016).

RESEARCH REGARDING CBD

Scientific professionals have researched a lot on CBD, and even still they are studying different aspects of CBD for the benefit of mankind. The probability of CBD was inquired about in which some individual were given 600 mg of CBD, and some were directed with 1200 mg of CBD. Individuals were kept on a twenty-eight-day followup which revealed that CBD was adequately tolerated by every individual who was incorporated into the examination (Pokorski, Clement, Phung, Weltman, & Fu, 2017).
In another study, a potential association of CBD with different drugs was assessed, It proposed safety outline of CBD in individuals. CBD enhances the speed of treatment when added to any treatment plan (Iffland & Grotenhermen, 2017).
A survey was introduced by Burstein Sumner on CBD’s consequences on the inflammation; it demonstrated that the receptor binding capacity and chemistry of CBD makes it a phenomenal compound of cannabis which is steady in managing inflammation (Burstein S. , 2015).

References

Burstein, S. (2015). Cannabidiol (CBD) and its analogs: a review of their effects on inflammation. Bioorganic \& medicinal chemistry, 23(7), 1377-1385.

Burstein, S. (2015). Cannabidiol (CBD) and its analogs: a review of their effects on inflammation. Bioorganic \& medicinal chemistry, 23(7), 1377-1385.

Devinsky, O., Cilio, M. R., Cross, H., Fernandez-Ruiz, J., French, J., Hill, C., & Katz, R. (2014). Cannabidiol: pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders. Epilepsia, 55(6), 791-802.

Iffland, K., & Grotenhermen, F. (2017). An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies. Cannabis and Cannabinoid Research, 2(1), 139-154.

Linge, R., Jim{\’e}nez-S{\’a}nchez, L., Campa, L., Pilar-Cu{\’e}llar, F., & Vidal, R. (2016). Cannabidiol induces rapid-acting antidepressant-like effects and enhances cortical 5-HT/glutamate neurotransmission: role of 5-HT 1A receptors. Neuropharmacology, 103, 16-26.

Mechoulam, R., Peters, M., Murillo-Rodriguez, E., & Hanu{\v{s}}, L. O. (2007). Cannabidiol–recent advances. Chemistry \& biodiversity, 4(8), 1678-1692.

Pokorski, I., Clement, N., Phung, N., Weltman, M., & Fu, S. (2017). Cannabidiol in the management of in-patient cannabis withdrawal: clinical case series. Future Neurology, 12(3), 133-140.

Russo, E. B. (2008). Cannabinoids in the management of difficult to treat pain. Therapeutics and Clinical Risk Management, 4(1), 245.

Tokes, R. (2016). What is CBD – The Truth about Cannabidiol – Medication.

Weiss, L., Zeira, M., Reich, S., Slavin, S., & Raz, I. (2008). Cannabidiol arrests onset of autoimmune diabetes in NOD mice. Neuropharmacology, 54(1), 244-249.

Zuardi, A. W., Crippa, J. A., Hallak, J., Bhattacharyya, S., & Atakan, Z. (2012). A critical review of the antipsychotic effects of cannabidiol: 30 years of a translational investigation. Curr Pharm Des, 18(32), 5131-40.

Benefits of CBD on Sleep

A lot of people battle with serious sleep issues. The International Classification of Sleep Disorders recognizes around eighty sleep-related issue. However, the prevalence, load, and management of sleep disorders are generally disregarded or neglected by people and society by and large.

Sleep

“Sleep is an active state of recovery during which the optimal function of all body systems is reinstated. Sleep repairs and prevents the occurrence of chronic diseases such as cancer, diabetes, and obesity” (Filip, et al., 2017).

Sleeping Pills are Harmful

Sleep pills are so common in society, every other person who feels like having sleep disorder takes help from sleep medicine. There has been extensive evidence of the cost-effectiveness of treating patients with obstructive sleep apnea, particularly concerning its high prevalence, morbidity, mortality, and corresponding health care utilization. The fact that sleeping pills have a lot of side effects including memory impairment, people who really need pills also avoid it. CBD (cannabidiol) is a blessing in such circumstances when one needs medical assistance without any side effects.

CBD

The immense therapeutic potential advantages of CBD helps in the treatment of many medical ailments. CBD diminishes the level of anxiety, possess anti-inflammatory characteristics, aids seizures, treat pain, provide neuroprotection and promotes better sleep  (ANXIETY HACK, 2018). CBD support physiological benefits generally by binding with CB1 and CB2 receptors on cells all through the body and brain. The World Anti-Doping Agency (WADA) has effectively eliminated CBD  obtained from hemp from the category of prohibited substances

CBD and Sleep

CBD is a part of Cannabis sativa that has a wide range of potential therapeutic effects in neuropsychiatric and other illnesses. Few examinations have researched the conceivable interference of CBD on the sleep-wake cycle. A research was led to assess the effect of a clinically anxiolytic dose of CBD on the sleep-wake cycle of healthy subjects. The research concluded that CBD does not alter normal sleep pattern  (Linares, Guimaraes, Eckeli, Crippa, & Zuardi, 2018).

Endocannabinoid system

A research known as Endocannabinoid modulation of cortical up-states and NREM sleep ended with the positive role of CBD in sleep pattern.  The EC system effectively regulates cortical up-states and important features of NREM sleep, for example, its length and low-frequency cortical oscillations. (Pava, den Hartog, Blanco-Centurion, & Shiromani, 2014)

CBD on sleep-wake cycle in rats

To prove the effectiveness of CBD with sleep issues, it first experimented in rats. A research was conducted to examine the effects on sleep of acute systemic administration of CBD. The study concluded that the acute systemic administration of CBD seems to expand the entire sleep time, also enhance sleep latency in the light time of the day of administration. (Chagas, 2013)

Sleep apnea

Rest apnea is a serious sleep issue, individuals who experience the ill effects of sleep apnea get repeatedly awakened by their very own breathing due to the constricted airway. In this way, a person feels tired even after a snoring sleep. It can cause hypertension, pressure, diabetes, fatigue, etc. Studies have uncovered that CBD decreases sleep apnea, as it is a muscle relaxant. CBD may treat sleep apnea efficiently (Powell, 2018 ).

The effects of cannabis extracts were studied on nocturnal sleep, early-morning performance, memory, and sleepiness. Positive outcomes of Delta-9-tetrahydrocannabinol and CBD on nocturnal sleep and early-morning behavior in young adults were observed (Nicholson, Turner, Stone, & Robson, 2004)

Chronic insomnia

Chronic insomnia is among the common sleep disorders caused because of the severe depression, stress, and discomfort at night time. Numerous individuals say that CBD oil has helped them sleep soundly. CBD oil got from the cannabis plant, plays a vital role in sleep. It’s a non-psychoactive compound of cannabis that doesn’t trigger any changed conditions of consciousness. The compound terpene myrcene present in CBD goes about as a herbal sedative and enhances the quality of sleep. When one has a good quality of sleep, it helps body repair, better cognition, and enhanced immunity.

Disturbed sleep due to Depression

After any injury people commonly complain about specific things, for example, disturbing dreams, such dreams irritate healthy sleep pattern, due to this people lead to depression which eventually results in sleep disorder. PTSD(post traumatic stress disorder) patients experience the adverse impacts of sleeping issue due to horrible dreams and severe depression. It has been suggested by a clinical trial that PTSD’s major symptom, i.e. bad dreams have been controlled through CBD (Fraser, 2009). CBD efficiently helps terrible dreams and depression and helps in the correct peaceful sleep. CBD has been seemed to have anxiolytic properties in patients diagnosed with PTSD  (Schier, Ribeiro, & Hallak, 2012).

References

ANXIETY HACK. (2018, Feburary 6). Is Cannabidiol (CBD): An Effective Anxiety Remedy? Retrieved from ANXIETYHACK.COM: http://www.anxietyhack.com/cannabidiol-cbd-nootropic-anxiety/

Chagas, M. H.-d.-S. (2013). Effects of acute systemic administration of cannabidiol on sleep-wake cycle in rats. Journal of Psychopharmacology, 312–316.

Filip, I., Tidman, M., Bennett, H., Wick, B., Rouse, N., Patriche, D., & Radfar, A. (2017). Public health burden of sleep disorders: underreported problem. Journal of Public Health, 25(3), 243–248.

Fraser, G. A. (2009). The use of a synthetic cannabinoid in the management of Treatment-Resistant nightmares in posttraumatic stress disorder (PTSD). CNS neuroscience \& therapeutics, 15(1), 84-88.

Linares, I. M., Guimaraes, F. S., Eckeli, A., Crippa, A., & Zuardi, A. W. (2018). No Acute Effects of Cannabidiol on the Sleep-Wake Cycle of Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study. Frontiers in pharmacology, 9, 315.

Nicholson, A. N., Turner, C., Stone, B. M., & Robson, P. J. (2004). Effect of $\Delta$-9-tetrahydrocannabinol and cannabidiol on nocturnal sleep and early-morning behavior in young adults. Journal of clinical psychopharmacology, 24(3), 305–313.

Pava, M. J., den Hartog, C. R., Blanco-Centurion, C., & Shiromani, P. J. (2014). Endocannabinoid modulation of cortical up-states and NREM sleep. PloS one, 9(2), e88672.

Powell, B. (2018 , May 4). New Research Shows That Cannabinoids May Treat Sleep Apnea. Retrieved from High Times: https://hightimes.com/news/new-research-shows-cannabinoids-may-treat-sleep-apnea/

Schier, A. R., Ribeiro, N. P., & Hallak, J. E. (2012). Cannabidiol, a Cannabis sativa constituent, as an anxiolytic drug. Revista Brasileira de Psiquiatria, 34, 104–110.

Benefits of CBD w/ Pets (How CBD is being used for pets)

CBD (Cannabidiol) has a powerful image around the globe. Medical industry greatly uses the benefits of CBD for curing various illnesses. CBD is a compound obtained from the cannabis plant that is also known as medical marijuana. The plant contains certain active compounds called as cannabinoids which are responsible for the effect of cannabis on individuals. CBD is the most important cannabinoid found in this plant. CBD is not only excellent for people, but it is also beneficial for pets.

Endocannabinoid System

The endocannabinoid system of human has a strong role with CBD. It joins with the cannabinoid receptors in various parts of the body predominantly in the Central nervous system by the antipsychotic effect (Tokes, 2016). Just like human, dogs, and cats also have an endocannabinoid system, which clearly means that animals can also avail the benefits of CBD just like human beings.

Benefits of CBD for pets

CBD can benefit pets for a large number of similar conditions it benefits their proprietors:

  • Pain

  • Inflammation

  • Seizure control

  • Enhance the quality of life

  • Appetite

  • Anxiety issues

  • Cancer

  • GI disorder

 

 

CBD oil with small amount of THC in it, Yes or no?

A little amount of THC in CBD oil is something worthy as it will offer an entourage effect. THC is just an issue for pets when they have it excessively. Always begin with a low amount of dose and work the way up gradually. Remember that one can simply give their pet more. However, it’s much harder to reverse a dose once administered.

 

Side Effect

Only a high amount of dosage can induce the prolonged sedative effect in pets. If the pet gets too sleepy after CBD dose, the amount of CBD should reduce the next time.

 

 

Mode of administration of CBD in pets

The best mode of administration of CBD in pets is the sublingual route. The best way for giving CBD to pets is a sublingual tincture (Nurse Your Pet, 2017). The sublingual tinctures easy to administer, easy to dose and are easy to adjust (the dose) in case any increase or decrease in the dose is required.

 

CBD dosage for pets

The standard dosage of CBD for pets considered safe is 0.05 mg per lb two times a day to 0.25 mg per lb two times a day.

Level 1: 0.05 mg/lb of the body weight is low-end

Level 2: 0.125 mg/lb of the body weight is a middle ground

Level 3: 0.25 mg/lb of the  body weight is high end

According to Dr. Silver, the dosage should begin from level 1 twice a day and should be monitored for over a week. It may not be important to go to level 2 if required then only go to level 2 and observe for a week. Furthermore, if important to go higher, go up to level 3 twice every day (Dr. Robert J Silve, 2015).

 

CBD for Dogs Suffering From Cancer

The Australian comprehensive veterinarian, Dr. Edward Bassingthwaighte had encountered genuine achievement when he treated dogs with CBD. He utilized CBD oil and other natural solutions to treat a dog with a developing tumor. The tumor measure was around 6 cm in diameter, and it was in the mammary gland of that dog. It took a tumor around a half year to shrink, and the dog did not encounter any reoccurrence too (HolistaPet Support Team, 2017)

 

 

CBD helps the Appetite of pets

As CBD is nonpsychoactive, it stimulates the appetite of the pets which is compulsory to keep a pet healthy and strong.

 

CBD can help with Seizures in pets

Seizures can be an agonizing health problem for your pet. They cause violent shaking, and you will not want to be a silent onlooker watching the agony of your pet. The biggest problem with seizures is that they can be quite difficult to treat. The advantage identified with the CBD oil is that it can without much of a stretch diminish the intensity of the seizures. It can decrease the electrical disruptions in the dog’s mind. This is one of the core advantages of CBD oil for dogs.

 

CBD for Pain and Inflammation in Pets

As it is already known that CBD helps people with inflammation and pain  (La Porta, Bura, Negrete, & Maldonado, 2014). It uses as an analgesic for pets as well In a research carried out on rats concerning CBD concluded that CBD is beneficial for the curing the inflammation and pain (Schuelert & McDougall, 2011).

 

References

Dr. Robert J Silve. (2015). “Is Medical Marijuana Right For Your Pet?”. Retrieved from http://www.potforpets.info/

HolistaPet Support Team. (2017, December 1). 12 Amazing Benefits of CBD Oil for Dogs. Retrieved from HolistaPet : https://holistapet.com/12-amazing-benefits-of-cbd-oil-for-dogs/

La Porta, C., Bura, S. A., Negrete, R., & Maldonado, R. (2014). Involvement of the endocannabinoid system in osteoarthritis pain. La Porta C1, Bura SA, Negrete R, Maldonado R. European Journal of Neuroscience, 39(3), 485–500.

Nurse Your Pet. (2017). HOW TO DOSE CANNABIS FOR YOUR PETS FOR BETTER EFFECT AND LESS SIDE-EFFECTS. Retrieved from Nurse Your Pet: http://nurseyourpet.com/how-to-dose-cannabis-for-your-pets-for-better-effect-and-less-side-effects/

Schuelert, N., & McDougall, J. J. (2011). he abnormal cannabidiol analogue O-1602 reduces nociception in a rat model of acute arthritis via the putative cannabinoid receptor GPR55. Neuroscience letters, 72–76.

Tokes, R. (2016). What is CBD – The Truth about Cannabidiol – Medication.