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Lab Results

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Depression

2010 – Study: Antidepressant-like effects of cannabidiol in mice: possible involvement of 5 HT receptors
2010 – Antidepressant-like effect of Delta (9)-tetrahydrocannabinol and other cannabinoids isolated from Hemp sativa

Anxiety

2010 – Study: Effects of cannabidiol on amphetamine-induced oxidative stress generation in an animal mode of mania
2010 – Therapeutical use of the cannabinoids in pyschiatry
2010 – A behavioural comparison of acute and chronic Delta9-tetrahydrocannabinol and cannabidiol in C57BL/6JArc mice
2010 – Neural bliss of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report
2011 – Effects of intracisternal administration of cannabidiol on the cardiovascular and behavioral responses to acute restraint stress
2011 – Cannabidiol potentiates Delta(9)-tetrahydrocannabinol (THC) behavioral effects and alters THC pharmacokinetics during acute and chronic treatment in adolescent rats
2011 – Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naive social phobia patients
2011 – Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report
2011 – The endocannabinoid system in the regulation of emotions throughout lifespan: a discussion on therapeutic perspectives
2012 – Cannabidiol, a Hemp sativa constituent, as an anxiolytic drug
2012 – On disruption of Fear Memory by Reconsolidation Blockade: Evidence from Cannabidiol Treatment

Seizures

2010 –  Anticonvulsant effects of GWP42006 in vitro and in vivo in rat
2010 –  Cannabidiol Displays Antiepileptiform and Antiseizure Properties In Vitro and In Vivo. 
2012 –  Cannabidiol exerts anti-convulsant effects in animal models of temporal lobe and partial seizures.

Memory

2010 – Key ingredient staves off marijuana memory loss.
2010 – Key ingredient dilutes marijuana’s effect on memory.
2010 – Impact of cannabidiol on the acute memory and psychotomimetic effects of smoked hemp: naturalistic study

Brain Damage

2010 –  Therapeutic Potential of Non-Psychotropic Cannabidiol in Ischemic Stroke.
2010 –  Effects of cannabidiol on amphetamine-induced oxidative stress generation in an animal model of mania.
2010 –  Cannabidiol ameliorates cognitive and motor impairments in bile-duct ligated mice via 5-HT1A receptor activation
2010 –  Opposite Effects of Δ-9-Tetrahydrocannabinol and Cannabidiol on Human Brain Function and Psychopathology
2010 –  Disposition of Cannabichromene, Cannabidiol, and Δ9-Tetrahydrocannabinol and its Metabolites in Mouse Brain following Marijuana Inhalation Determined by High-Performance Liquid Chromatography-Tandem Mass Spectrometry
2010 –  Treatment with cannabidiol reverses oxidative stress parameters, cognitive impairment and mortality in rats submitted to sepsis by cecal ligation and puncture
2010 –  The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic-ischemic brain damage in mice is mediated by CB(2) and adenosine receptors
2010 –  Cannabinoid receptor CB1 mediates baseline and activity-induced survival of new neurons in adult hippocampal neurogenesis
2011 –  Cannabidiol reduces brain damage and improves functional recovery after acute hypoxia-ischemia in newborn pigs

Parkinson’s Disease

2010 – Brazilian Scientists Show How Marijuana Can Help in Treating Parkinson

Alzheimer’s Disease & Dementia

2011 –  Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimers’ disease
2011 –  US Patent Application 20110257256 – CANNABINOIDS FOR USE IN TREATING OR PREVENTING COGNITIVE IMPAIRMENT AND DEMENTIA
2011 –  Memory-rescuing effects of cannabidiol in an animal model of cognitive impairment relevant to neurodegenerative disorders
2011 –  Prospects for cannabinoid therapies in basal ganglia disorders
2011 –  Phytocannabinoids as novel therapeutic agents in CNS disorders
2011 –  Memory-rescuing effects of cannabidiol in an animal model of cognitive impairment relevant to neurodegenerative disorders
2012 –  The therapeutic potential of the endocannabinoid system for Alzheimer’s disease
2012 –  Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid

Breast Cancer

2011 – Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis
2011 – Cannabidiol induces programmed cell death in breast cancer cells by coordinating the crosstalk between apoptosis and autophagy

Cancer Cells

2010 – Antitumorigenic Effects of Cannabinoids beyond Apoptosis
2010 – Anti-tumoural effects of cannabinoid combinations – Patent TW201002315 (A)
2010 – Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases
2010 – Cannabidiol Enhances the Inhibitory Effects of Delta9 – Tetrahydrocannabinol on Human Glioblastoma Cell Proliferation and Survival
2010 – Cannabidiol attenuates delayed-type hypersensitivity reactions via suppressing T-cell and macrophage reactivity
2010 – Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of efficacy, safety, and tolerability of THC
2011 – Phytocannabinoids for use in the treatment of cancer – Patent GB2478595(A) 
2011 – Cannabidiol induced a contrasting pro-apoptotic effect between freshly isolated and precultured human monocytes
2012 – Cannabidiol Inhibits Angiogenesis by Multiple Mechanisms
2012 – Poly-e-caprolactone microspheres as a drug delivery system for cannabinoid administration: Development characterization and in vitro evaluation of their antitumoral efficacy2012 – Cannabidiol-induced apoptosis in murine microglial cells through lipid raft

Lung Cancer

2010 –  Decrease of plasminogen activator inhibitor-1 may contribute to the anti-invasive action of cannabidiol on human lung cancer cells.

Brain Cancer

2010 – Science: Cannabidiol enhances the anti-cancer effects of THC on human brain cancer cells.

Colon Cancer

2011 –  Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent 
2012 –  Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer
2010 –  Cannabinoid-mediated modulation of neuropathic pain and microglial accumulation in a model of murine type I diabetic peripheral neuropathic pain.
2010 – Cannabinoids inhibit and may prevent neuropathic pain in diabetes.
2012 –  Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors.

Arrythmias

2010 – Acute administration of cannabidiol in vivo suppresses ischaemia-induced cardiac arrhythmias and reduces infarct size when given at reperfusion.
2010 – Cannabidiol (CBD) as an Anti-Arrhythmic – the Role of the CB1 Receptors.
2011 – Cannabidiol (CBD) as an Anti-Arrhythmic.

Diabetes

2010 – Cannabidiol Attenuates Cardiac Dysfunction, Oxidative Stress, Fibrosis, and Inflammatory and Cell Death Signaling Pathways in Diabetic Cardiomyopathy.
2010 – Pot Compound Mitigates Diabetic Cardiomyopathy.
2010 – Lab Notes: Pot Has Benefits for Diabetic Hearts.
2011 – The potential for clinical use of cannabinoids in treatment of cardiovascular diseases.
2011 – Cannabidiol as an anti-arrhythmic, the role of the CB1 receptors.
2012 – Islet protection and amelioration of diabetes type 2 in Psammomys obesus by treatment with cannabidiol.

Cholesterol

2011 – The Non-Psychoactive Plant Cannabinoid, Cannabidiol Affects Cholesterol Metabolism-Related Genes in Microglial Cells.

Obesity

2011 – Cannabidiol decreases body weight gain in rats: Involvement of CB2 receptors.

Inflammation

2010 – Diabetic retinopathy: Role of inflammation and potential therapies for anti-inflammation.
2012 – Cannabidiol, a non-psychotropic plant-derived cannabinoid, decreases inflammation in a murine model of acute lung injury: Role for the adenosine A(2A) receptor.
2012 – Cannabidiol in Inflammatory Bowel Diseases: A Brief Overview.

Arthritis

2000 – The nonpsychoactive hemp constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis

Nausea

2010 – Regulation of nausea and vomiting by cannabinoids.
2011 – Interaction between non-psychotropic cannabinoids in marihuana: effect of cannabigerol (CBG) on the anti-nausea or anti-emetic effects of cannabidiol (CBD) in rats and shrews.
2011 – Cannabidiol, a Non-Psychotropic Component of Hemp, Attenuates Vomiting and Nausea-like Behaviour via Indirect Agonism of 5-HT(1A) Somatodendritic: Autoreceptors in the Dorsal Raphe Nucleus.
2011 – Cannabidiol, a Non-Psychotropic Component of Hemp, Attenuates Vomiting and Nausea-like Behaviour via Indirect Agonism of 5-HT(1A) Somatodendritic: Autoreceptors in the Dorsal Raphe Nucleus.
2011 – Regulation of nausea and vomiting by cannabinoids.

Appetite

2010 – Cannabidiol Attenuates the Appetitive Effects of Δ9-Tetrahydrocannabinol in Humans Smoking Their Chosen Hemp.
2012 – Cannabinol and cannabidiol exert opposing effects on rat feeding patterns.

Pain Studies

2010 – Cannabinoid-mediated modulation of neuropathic pain and microglial accumulation in a model of murine type I diabetic peripheral neuropathic pain.
2010 – Cannabinoids inhibit and may prevent neuropathic pain in diabetes.
2012 – Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors.