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Lab Results
Depression
2010 – Study: Antidepressant-like effects of cannabidiol in mice: possible involvement of 5 HT receptors
2010 – Antidepressant-like effect of Delta (9)-tetrahydrocannabinol and other cannabinoids isolated from Hemp sativa
Anxiety
2010 – Study: Effects of cannabidiol on amphetamine-induced oxidative stress generation in an animal mode of mania
2010 – Therapeutical use of the cannabinoids in pyschiatry
2010 – A behavioural comparison of acute and chronic Delta9-tetrahydrocannabinol and cannabidiol in C57BL/6JArc mice
2010 – Neural bliss of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report
2011 – Effects of intracisternal administration of cannabidiol on the cardiovascular and behavioral responses to acute restraint stress
2011 – Cannabidiol potentiates Delta(9)-tetrahydrocannabinol (THC) behavioral effects and alters THC pharmacokinetics during acute and chronic treatment in adolescent rats
2011 – Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naive social phobia patients
2011 – Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report
2011 – The endocannabinoid system in the regulation of emotions throughout lifespan: a discussion on therapeutic perspectives
2012 – Cannabidiol, a Hemp sativa constituent, as an anxiolytic drug
2012 – On disruption of Fear Memory by Reconsolidation Blockade: Evidence from Cannabidiol Treatment
Seizures
2010 – Anticonvulsant effects of GWP42006 in vitro and in vivo in rat
2010 – Cannabidiol Displays Antiepileptiform and Antiseizure Properties In Vitro and In Vivo.
2012 – Cannabidiol exerts anti-convulsant effects in animal models of temporal lobe and partial seizures.
Memory
2010 – Key ingredient staves off marijuana memory loss.
2010 – Key ingredient dilutes marijuana’s effect on memory.
2010 – Impact of cannabidiol on the acute memory and psychotomimetic effects of smoked hemp: naturalistic study
Brain Damage
2010 – Therapeutic Potential of Non-Psychotropic Cannabidiol in Ischemic Stroke.
2010 – Effects of cannabidiol on amphetamine-induced oxidative stress generation in an animal model of mania.
2010 – Cannabidiol ameliorates cognitive and motor impairments in bile-duct ligated mice via 5-HT1A receptor activation
2010 – Opposite Effects of Δ-9-Tetrahydrocannabinol and Cannabidiol on Human Brain Function and Psychopathology
2010 – Disposition of Cannabichromene, Cannabidiol, and Δ9-Tetrahydrocannabinol and its Metabolites in Mouse Brain following Marijuana Inhalation Determined by High-Performance Liquid Chromatography-Tandem Mass Spectrometry
2010 – Treatment with cannabidiol reverses oxidative stress parameters, cognitive impairment and mortality in rats submitted to sepsis by cecal ligation and puncture
2010 – The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic-ischemic brain damage in mice is mediated by CB(2) and adenosine receptors
2010 – Cannabinoid receptor CB1 mediates baseline and activity-induced survival of new neurons in adult hippocampal neurogenesis
2011 – Cannabidiol reduces brain damage and improves functional recovery after acute hypoxia-ischemia in newborn pigs
Parkinson’s Disease
2010 – Brazilian Scientists Show How Marijuana Can Help in Treating Parkinson
Alzheimer’s Disease & Dementia
2011 – Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimers’ disease
2011 – US Patent Application 20110257256 – CANNABINOIDS FOR USE IN TREATING OR PREVENTING COGNITIVE IMPAIRMENT AND DEMENTIA
2011 – Memory-rescuing effects of cannabidiol in an animal model of cognitive impairment relevant to neurodegenerative disorders
2011 – Prospects for cannabinoid therapies in basal ganglia disorders
2011 – Phytocannabinoids as novel therapeutic agents in CNS disorders
2011 – Memory-rescuing effects of cannabidiol in an animal model of cognitive impairment relevant to neurodegenerative disorders
2012 – The therapeutic potential of the endocannabinoid system for Alzheimer’s disease
2012 – Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid
Breast Cancer
2011 – Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis
2011 – Cannabidiol induces programmed cell death in breast cancer cells by coordinating the crosstalk between apoptosis and autophagy
Cancer Cells
2010 – Antitumorigenic Effects of Cannabinoids beyond Apoptosis
2010 – Anti-tumoural effects of cannabinoid combinations – Patent TW201002315 (A)
2010 – Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases
2010 – Cannabidiol Enhances the Inhibitory Effects of Delta9 – Tetrahydrocannabinol on Human Glioblastoma Cell Proliferation and Survival
2010 – Cannabidiol attenuates delayed-type hypersensitivity reactions via suppressing T-cell and macrophage reactivity
2010 – Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of efficacy, safety, and tolerability of THC
2011 – Phytocannabinoids for use in the treatment of cancer – Patent GB2478595(A)
2011 – Cannabidiol induced a contrasting pro-apoptotic effect between freshly isolated and precultured human monocytes
2012 – Cannabidiol Inhibits Angiogenesis by Multiple Mechanisms
2012 – Poly-e-caprolactone microspheres as a drug delivery system for cannabinoid administration: Development characterization and in vitro evaluation of their antitumoral efficacy2012 – Cannabidiol-induced apoptosis in murine microglial cells through lipid raft
Lung Cancer
Brain Cancer
2010 – Science: Cannabidiol enhances the anti-cancer effects of THC on human brain cancer cells.
Colon Cancer
2011 – Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent
2012 – Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer
2010 – Cannabinoid-mediated modulation of neuropathic pain and microglial accumulation in a model of murine type I diabetic peripheral neuropathic pain.
2010 – Cannabinoids inhibit and may prevent neuropathic pain in diabetes.
2012 – Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors.
Arrythmias
2010 – Acute administration of cannabidiol in vivo suppresses ischaemia-induced cardiac arrhythmias and reduces infarct size when given at reperfusion.
2010 – Cannabidiol (CBD) as an Anti-Arrhythmic – the Role of the CB1 Receptors.
2011 – Cannabidiol (CBD) as an Anti-Arrhythmic.
Diabetes
2010 – Cannabidiol Attenuates Cardiac Dysfunction, Oxidative Stress, Fibrosis, and Inflammatory and Cell Death Signaling Pathways in Diabetic Cardiomyopathy.
2010 – Pot Compound Mitigates Diabetic Cardiomyopathy.
2010 – Lab Notes: Pot Has Benefits for Diabetic Hearts.
2011 – The potential for clinical use of cannabinoids in treatment of cardiovascular diseases.
2011 – Cannabidiol as an anti-arrhythmic, the role of the CB1 receptors.
2012 – Islet protection and amelioration of diabetes type 2 in Psammomys obesus by treatment with cannabidiol.
Cholesterol
Obesity
2011 – Cannabidiol decreases body weight gain in rats: Involvement of CB2 receptors.
Inflammation
2010 – Diabetic retinopathy: Role of inflammation and potential therapies for anti-inflammation.
2012 – Cannabidiol, a non-psychotropic plant-derived cannabinoid, decreases inflammation in a murine model of acute lung injury: Role for the adenosine A(2A) receptor.
2012 – Cannabidiol in Inflammatory Bowel Diseases: A Brief Overview.
Arthritis
Nausea
2010 – Regulation of nausea and vomiting by cannabinoids.
2011 – Interaction between non-psychotropic cannabinoids in marihuana: effect of cannabigerol (CBG) on the anti-nausea or anti-emetic effects of cannabidiol (CBD) in rats and shrews.
2011 – Cannabidiol, a Non-Psychotropic Component of Hemp, Attenuates Vomiting and Nausea-like Behaviour via Indirect Agonism of 5-HT(1A) Somatodendritic: Autoreceptors in the Dorsal Raphe Nucleus.
2011 – Cannabidiol, a Non-Psychotropic Component of Hemp, Attenuates Vomiting and Nausea-like Behaviour via Indirect Agonism of 5-HT(1A) Somatodendritic: Autoreceptors in the Dorsal Raphe Nucleus.
2011 – Regulation of nausea and vomiting by cannabinoids.
Appetite
2010 – Cannabidiol Attenuates the Appetitive Effects of Δ9-Tetrahydrocannabinol in Humans Smoking Their Chosen Hemp.
2012 – Cannabinol and cannabidiol exert opposing effects on rat feeding patterns.
Pain Studies
2010 – Cannabinoid-mediated modulation of neuropathic pain and microglial accumulation in a model of murine type I diabetic peripheral neuropathic pain.
2010 – Cannabinoids inhibit and may prevent neuropathic pain in diabetes.
2012 – Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors.
